• Artificial Intelligence Implementation in Healthcare: A Theory-Based Scoping Review of Barriers and Facilitators 

      Chomutare, Taridzo Fred; Tejedor Hernandez, Miguel Angel; Olsen Svenning, Therese; Ruiz, Luis Marco; Tayefi Nasrabadi, Maryam; Lind, Karianne Fredenfeldt; Godtliebsen, Fred; Moen, Anne; Ismail, Leila; Makhlysheva, Alexandra; Ngo, Phuong (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-06)
      There is a large proliferation of complex data-driven artificial intelligence (AI) applications in many aspects of our daily lives, but their implementation in healthcare is still limited. This scoping review takes a theoretical approach to examine the barriers and facilitators based on empirical data from existing implementations. We searched the major databases of relevant scientific publications ...
    • Automatic detection of the mental foramen for estimating mandibular cortical width in dental panoramic radiographs: the seventh survey of the Tromsø Study (Tromsø7) in 2015-2016 

      Edvardsen, Isak Paasche; Teterina, Anna; Johansen, Thomas Haugland; Myhre, Jonas Nordhaug; Godtliebsen, Fred; Bolstad, Napat Limchaichana (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)
      Objective To apply deep learning to a data set of dental panoramic radiographs to detect the mental foramen for automatic assessment of the mandibular cortical width.<p> <p>Methods Data from the seventh survey of the Tromsø Study (Tromsø7) were used. The data set contained 5197 randomly chosen dental panoramic radiographs. Four pretrained object detectors were tested. We randomly chose 80% of the ...
    • Automatic nematode detection in cod fillets (Gadus morhua L.) by hyperspectral imaging 

      Sivertsen, Agnar Holten; Heia, Karsten; Hindberg, Kristian; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Detection of objects embedded in tissue, using visible light, is difficult due to light scattering. The optical properties of the surrounding tissue will influence the spectral characteristics of the light interacting with the object, and the spectral signature observed from the object will be directly affected. A method for calibrating the spectral signature of small objects, embedded in translucent ...
    • Automatic Segmentation of Dermoscopic Images by Iterative Classification 

      Zortea, Maciel; Skrøvseth, Stein Olav; Schopf, Thomas Roger Griesbeck; Kirchesch, Herbert M.; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Accurate detection of the borders of skin lesions is a vital first step for computer aided diagnostic systems. This paper presents a novel automatic approach to segmentation of skin lesions that is particularly suitable for analysis of dermoscopic images. Assumptions about the image acquisition, in particular, the approximate location and color, are used to derive an automatic rule to select small ...
    • Bayesian modeling and significant features exploration in wavelet power spectra 

      Divine, Dmitry V; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)
    • Bayesian multiscale analysis of images modeled as Gaussian Markov random fields 

      Thon, Kevin Otto; Rue, Håvard; Skrøvseth, Stein Olav; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      A Bayesian multiscale technique for the detection of statistically significant features in noisy images is proposed. The prior is defined as a stationary intrinsic Gaussian Markov random field on a toroidal graph, which enables efficient computation of the relevant posterior marginals. Hence the method is applicable to large images produced by modern digital cameras. The technique is demonstrated ...
    • Causality in Scale Space as an Approach to Change Detection 

      Skrøvseth, Stein Olav; Godtliebsen, Fred; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Kernel density estimation and kernel regression are useful ways to visualize and assess the structure of data. Using these techniques we define a temporal scale space as the vector space spanned by bandwidth and a temporal variable. In this space significance regions that reflect a significant derivative in the kernel smooth similar to those of SiZer (Significant Zero-crossings of derivatives) are ...
    • Challenges and opportunities beyond structured data in analysis of electronic health records 

      Tayefi, Maryam; Ngo, Phuong; Chomutare, Taridzo; Dalianis, Hercules; Salvi, Elisa; Budrionis, Andrius; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-14)
      Electronic health records (EHR) contain a lot of valuable information about individual patients and the whole population. Besides structured data, unstructured data in EHRs can provide extra, valuable information but the analytics processes are complex, time-consuming, and often require excessive manual effort. Among unstructured data, clinical text and images are the two most popular and important ...
    • Comparison of computer systems and ranking criteria for automatic melanoma detection in dermoscopic images 

      Møllersen, Kajsa; Zortea, Maciel; Schopf, Thomas Roger Griesbeck; Kirchesch, Herbert M.; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Melanoma is the deadliest form of skin cancer, and early detection is crucial for patient survival. Computer systems can assist in melanoma detection, but are not widespread in clinical practice. In 2016, an open challenge in classification of dermoscopic images of skin lesions was announced. A training set of 900 images with corresponding class labels and semi-automatic/manual segmentation masks ...
    • Computer-aided decision support for melanoma detection applied on melanocytic and non-melanocytic skin lesions: a comparison of two systems based on automatic analysis of dermoscopic images 

      Møllersen, Kajsa; Kirchesch, Herbert M.; Zortea, Maciel; Schopf, Thomas Roger Griesbeck; Hindberg, Kristian; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Commercially available clinical decision support systems (CDSSs) for skin cancer have been designed for the detection of melanoma only. Correct use of the systems requires expert knowledge, hampering their utility for nonexperts. Furthermore, there are no systems to detect other common skin cancer types, that is, nonmelanoma skin cancer (NMSC). As early diagnosis of skin cancer is essential, there ...
    • Control of Blood Glucose for Type-1 Diabetes by Using Reinforcement Learning with Feedforward Algorithm 

      Ngo, Phuong; Wei, Susan; Holubova, Anna; Muzik, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)
      <p><i>Background</i>: Type-1 diabetes is a condition caused by the lack of insulin hormone, which leads to an excessive increase in blood glucose level. The glucose kinetics process is difficult to control due to its complex and nonlinear nature and with state variables that are difficult to measure.</p> <p><i>Methods</i>: This paper proposes a method for automatically calculating the basal and ...
    • Curve-Based Classification Approach for Hyperspectral Dermatologic Data Processing 

      Uteng, Stig; Quevedo, Eduardo; Callico, Gustavo M.; Castaño, Irene; Carretero, Gregorio; Almeida, Pablo; Garcia, Aday; Hernandez, Javier A.; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-20)
      This paper shows new contributions in the detection of skin cancer, where we present the use of a customized hyperspectral system that captures images in the spectral range from 450 to 950 nm. By choosing a 7 × 7 sub-image of each channel in the hyperspectral image (HSI) and then taking the mean and standard deviation of these sub-images, we were able to make fits of the resulting curves. These ...
    • Data-Driven Robust Control Using Reinforcement Learning 

      Ngo, Phuong; Tejedor Hernandez, Miguel Angel; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-21)
      This paper proposes a robust control design method using reinforcement learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement learning algorithm with a new learning technique based on the robust control theory. By learning from the data, the algorithm proposes actions that guarantee the stability of the closed-loop system ...
    • De-identifying Swedish EHR text using public resources in the general domain 

      Chomutare, Taridzo; Yigzaw, Kassaye Yitbarek; Budrionis, Andrius; Makhlysheva, Alexandra; Godtliebsen, Fred; Dalianis, Hercules (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
      Sensitive data is normally required to develop rule-based or train machine learning-based models for de-identifying electronic health record (EHR) clinical notes; and this presents important problems for patient privacy. In this study, we add non-sensitive public datasets to EHR training data; (i) scientific medical text and (ii) Wikipedia word vectors. The data, all in Swedish, is used to train a ...
    • Early Detection of Change by Applying Scale-Space Methodology to Hyperspectral Images 

      Uteng, Stig; Johansen, Thomas Haugland; Zaballos, Jose Ignacio; Ortega, Samuel; Holmström, Lasse; Callico, Gustavo M.; Fabelo, Himar; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-27)
      Given an object of interest that evolves in time, one often wants to detect possible changes in its properties. The first changes may be small and occur in different scales and it may be crucial to detect them as early as possible. Examples include identification of potentially malignant changes in skin moles or the gradual onset of food quality deterioration. Statistical scale-space methodologies ...
    • The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig 

      Hammond, John S.; Godtliebsen, Fred; Steigen, Sonja Eriksson; Guha, I. Neil; Wyatt, Judy; Revhaug, Arthur; Lobo, Dileep N.; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)
      Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine ...
    • Elemental carbon measurements in European Arctic snow packs 

      Forsström, S.; Isaksson, Elisabeth; Skeie, Ragnhild Bieltvedt; Ström, Johan; Pedersen, CA; Hudson, S.R.; Berntsen, Terje Koren; Lihavainen, H.; Godtliebsen, Fred; Gerland, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-12-26)
      Black carbon (BC) and other light-absorbing particles deposited on snow and ice are known to perturb the surface radiative balance. There are few published observations of the concentration of these particles in the snow in Scandinavia and the European Arctic. We measured BC concentrations in snow samples collected in this region from 2007 to 2009, and we present the results here. The data set ...
    • Estimation of Blood Glucose Concentration During Endurance Sports 

      Sebastiani, Giovanni; Uteng, Stig; Godtliebsen, Fred; Polàk, Jan; Brož, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-21)
      In this paper, we describe a new statistical approach to estimate blood glucose concentration along time during endurance sports based on measurements of glucose concentration in subcutaneous interstitial tissue. The final goal is the monitoring of glucose concentration in blood to maximize performance in endurance sports. Blood glucose concentration control during and after aerobic physical ...
    • Evaluating Deep Q-Learning Algorithms for Controlling Blood Glucose in In Silico Type 1 Diabetes 

      Angel, Tejedor H Miguel; Hjerde, Sigurd; Myhre, Jonas Nordhaug; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)
      Patients with type 1 diabetes must continually decide how much insulin to inject before each meal to maintain blood glucose levels within a healthy range. Recent research has worked on a solution for this burden, showing the potential of reinforcement learning as an emerging approach for the task of controlling blood glucose levels. In this paper, we test and evaluate several deep Q-learning algorithms ...
    • Food recommendation using machine learning for physical activities in patients with type 1 diabetes 

      Ngo, Phuong; Tayefi, Maryam; Nordsletta, Anne Torill; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      Physical activities have a significant impact on blood glucose homeostasis of patients with type 1 diabetes. Regular physical exercise provides many proven health benefits and is recommended as part of a healthy lifestyle. However, one of the main side effects of physical activities is hypoglycemia (low blood glucose). Fear of hypoglycemia generally leads to the patients not participating in ...